Professor Deling Kong
Email Address: kongdeling@nankai.edu.cn
Telephone: (+86)022-23502155
Office Location: Room 512B, New Comprehensive Laboratory Building B, Jinnan Campus, Nankai University
Research Interests: Cardiovascular biomaterials, tissue engineering, regenerative medicine
(1)Small-diameter artificial vascular graft materials: focusing on the construction of multifunctional bioactive vascular scaffold materials. My team’s research involves the optimization of biodegradable micro-nano vascular materials prepared by electrospinning and melt-spinning with precision-controlled pore structure, fiber orientation, mechanical properties, and degradation behavior. We also modify vascular materials to convey bioactivity and functionalization (through affixed growth factors, anticoagulant molecules, endothelial cells/receptors, vasoactive substances). Together with our studies into achieving rapid cell ingrowth, endothelialization, functional vascular layer formation, and complete degradation of implanted materials, we aim to achieve the complete regeneration of blood vessels that are structurally and functionally the same as natural blood vessels – ensuring their long-term maintenance of patency.
(2) Stem cell therapy for ischemic diseases: research into the use of stem cell therapy for myocardial ischemia, lower limb ischemia, renal ischemia, and other ischemic diseases. Mainly, we use mesenchymal stem cells (MSC) and induced pluripotent stem cells (iPSC) in combination with vector materials, such as bioactive hydrogels. We aim to understand how to regulate the proliferation, differentiation, and secretome profile of stem cells to improve the survival rate of transplanted stem cells. We have also developed novel molecular probes to trace the behavior, function, and fate of transplanted stem cells in vivo. In addition, we aim to understand the effects of material and engineering methodology on stem cell function and the regulation of exosome secretion, to maximize the therapeutic effect, stemness, and survival rate of engrafted stem cells.
(3) Other biological materials, including drug-controlled release, nano-drugs, nano-vaccines: including nerve, skin, cartilage, and other applications of regenerative materials on tissue repair.
Academic Experience:
Work:
2018/11 – Present: Head of Science and Technology Department, Nankai University
2003/09 – Present: Professor and Ph.D. Supervisor, College of Life Sciences, Nankai University
2017/06 – 2018/11: Dean, College of Life Sciences, Nankai University
2004/12 – 2017/06: Director, Key Laboratory of Bioactive Materials, Ministry of Education
2007/12 – 2008/02: Visiting Scholar, Department of Cardiovascular Surgery, University Hospital of Geneva, Switzerland, Project: Tissue Engineering of Blood Powders. Mentor: Beat H. Walpoth
2006/11 – 2007/02: Visiting Scholar, Department of Physiology, Queen's University of Canada, Project: Stem Cell Based and Pharmacological Treatments for Heart Diseases. Mentor: Luis G. Melo
1998/09 – 2000/09: Postdoctoral Researcher, Centre for Bioengineering, Rostock, Germany, Project: Immunosorbents for Rheumatoid Arthritis and Systemic Lupus Erythematosus. Supervisor: Horst Klinkmann
1997/06 – 1998/09: Postdoctoral Researcher, Harvard Medical School, Project: Bone Marrow Derived Stem Cell and Gene Therapies for Cardiovascular Diseases. Supervisor: Victor J. Dzau
Education:
1994/09 – 1997/06: Ph.D. Polymer Chemistry and Physics, Nankai University, Supervisor: Yaoting Yu
1989/09 – 1992/07: MSc Polymer Chemistry and Physics, Nankai University, Supervisor: Juntan Sun
1985/09 – 1989/07: BSc Chemistry, Nankai University
Appointments:
Fellow of the International Federation of Biological Materials and Engineering (2016)
Standing Member, Medical Device Management Professional Committee, China Medical Education Association
Executive Director of the 9th Session, Chinese Society of Biomedical Engineering
Invited Member of the 10th Session, Chinese Society of Biomedical Engineering
Executive Director of the 1st Session, China Biomaterials Society
Standing Director of the 2nd Session, China Biomaterials Society
Vice Chairman, Cardiovascular Biomaterials Branch, Chinese Society of Biomaterials
Invited Member of the 1st Session, Standing Committee of Nanomaterials Branch, Chinese Society of Biomaterials
Standing Member of the 1st Session, Youth Committee of China Biomaterial Society
Invited Member of the 1st Session, Technical Committee, Engineering Research Center of Cardiovascular Interventional Therapy, Ministry of Education
Invited Member of the 1st Session, Standing Committee of Vascular Equipment Branch of China Medical Device Industry Association
Standing Committee Member and Deputy Director, National and Local Joint Engineering Laboratory for Vascular Implant Development (Chongqing) Academic Committee,
Director, Key Laboratory of Bioactive Materials, Ministry of Education
Council Member, International Society for Blood Purification (Head, Pacific Rim Office)
Director, China Society of Materials
Vice President, Tianjin Biomedical Engineering Society
Vice-Chairman of the Organization Engineering Sub-committee, Tianjin Biomedical Engineering Society
Member of the International Society of Artificial Organs
Member of the Academic Committee, State Key Laboratory of Experimental Hematology
Member of the Academic Committee, Key Laboratory of Biomechanics and Force Biology, Ministry of Education, Beihang University
Member of the Expert Committee, Tan Jiazhen Life Science Award
Vice Chairman of the Academic Committee, Tianjin Key Laboratory of Biomedical Materials
Member of the Academic Committee, Shandong Key Laboratory of Biomedical Materials
Member of the Academic Committee, Engineering Research Center of Cardiovascular Interventional Therapy Technology and Apparatus, Ministry of Education (Zhongshan Hospital, Fudan University)
Member of the 11th and 12th Expert Evaluation Groups, Life Science Department of the National Natural Science Foundation of China (NSFC)
Member of the Joint Review Panel of Key Projects, NSFC, Ministry of Life Sciences (2006)
Member of the National Outstanding Youth Foundation Review Panel, Ministry of Life Sciences (2009)
Member of the Key Project Review Expert Panel, Natural Science Foundation of the Department of Life Sciences (2009)
Member of the Expert Group, 12th Five-Year Plan on Discipline Development Strategy Research (Cross-discipline Group), Life Sciences Department,
Evaluation Expert, China Scholarship Council
Member of the 1st Special Expert Committee, Development of National Major Scientific Instruments and Equipment
Editorial Board, Journal of Tissue Engineering and Regenerative Medicine
Editorial Board, Regenerative Biomaterials F.
Editorial Board, Chinese Journal of Biomedical Engineering
Editor, International Journal of Biomedical Engineering
Awards & Honors:
2020 - Gold Medal Award, The 5th China Internet and College Student Innovation and Entrepreneurship Competition, Group Mentor for, “the world's first innovative first-generation neural catheter.”
2020 - Tianjin Model Research Group Award, Cardiovascular Biomaterials and Tissue Engineering Team
2019 - 1st Prize of Tianjin Natural Science Foundation for, “the pro-angiogenic effect of bioactive materials in the treatment of ischemic diseases.”
2018 - 2nd Prize of Tianjin Natural Science Foundation for, “the molecular mechanisms of hydrophobic protein self-assembly of fungi and the function of material surface modification.”
2018 - Honorary Title of Advanced Organization of the All-China Federation of Overseas Chinese, the 10th National Congress of Returned Overseas Chinese and Their Families, Cardiovascular Tissue Engineering Team
2018 - 2nd Prize of Tianjin Natural Science Foundation for, “the molecular mechanism of hydrophobic protein self-assembly of fungi and the function of material surface modification”.
2018 - 2nd Prize of Tianjin Science and Technology Progress Award for, “the construction and application of nanometer and hydrogel carriers for delivery of bioactive substances.”
2016 - 2nd Prize of Tianjin Science and Technology Progress Award for, “basic and applied research on new treatments of diabetes complicated with cardiovascular disease”.
2015 - 2nd Prize of Tianjin Science and Technology Progress Award for, “the construction and application of nano-system for early tumor diagnosis and targeted therapy.”
2014 - 1st Prize of Tianjin Natural Science Foundation for, “supramolecular hydrogel preparation and biomedical application.”
2013 - Government Research Allowance, State Council
2010 - Distinguished Professor of Scholars, Peking Union Medical College
2010 - 2nd Prize of Tianjin Natural Science Foundation for, “cardiovascular tissue engineering research in combination with stem cell and gene therapy.”
2009 - National Candidate of the New Century Talent Project
2009 - 2nd Prize of National Science and Technology Progress Award for, “the creation of high-performance blood purification medical adsorption resin.”
2007 - National Outstanding Youth Science Foundation Project
2006 – 2nd Prize Tianjin Science and Technology Award for, “development and research of four kinds of blood purification adsorbents, including Lupus DNA immunosorbents.”
2006 - 1st Prize of the 8th Tianjin Youth Science and Technology Award
2004 - New Century Excellent Talents Support Program, Ministry of Education
